.: MU CVM VMDB - Abstracts :.

	EVALUATION OF RISK AND CLINICAL OUTCOME OF MAST CELL TUMOURS IN PUG DOGS
Authors: McNeil EA, Prink AL, O'Brien DJ Publications: Vet Comp Oncol 2006;4: Species: Dogs Diseases: Mast Cell Tumors
Abstract / PubMed Link : Evaluation of risk and clinical outcome of mast cell tumours in pug dogs
Mast cell tumours (MCT) are common in dogs and characterized by diverse biologic behaviour. Our objective was to evaluate the risk of MCT in pugs and to describe the clinical behaviour of MCT in this breed. Data obtained from the Veterinary Medicine Database demonstrate significantly increased frequency of MCT in pugs compared with other dogs (OR = 2.28, 95% CI = 1.81–2.86). The medical records for 25 purebred pugs with a histologic diagnosis of MCT were reviewed. Multiple cutaneous tumours were documented in 14 (56 %) of the dogs. Histologic review of 64 tumours from these dogs confirmed that most tumours (94%) were low to intermediate grade. Sixty-four per cent of these dogs are still living, while only three dogs (12%) have died due to mast cell disease. A median survival time has not been reached. The median follow-up time is 660 days from the diagnosis of the first MCT. We conclude that MCT in pugs are relatively benign, despite the presence of multiple cutaneous tumours in most cases. Multiple tumours in breeds with predisposition to MCT may indicate separate primaries rather than advanced stage disease.
Date Created : 4/4/2009 Date Updated : 4/4/2009
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