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Authors: Huang A A, Moore G E, Scott-Moncrieff J C
Publications: J Vet Intern Med 2012;26:142-148
Species: Dogs, Dogs
Diseases: Immune mediated disease, Immune mediated disease
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"BACKGROUND:
Vaccination is often cited as a potential cause of immune-mediated thrombocytopenia (ITP) in dogs. Although an association has been documented in humans, particularly in children, this relationship has not been definitively established in dogs. OBJECTIVES:
To identify the presence of an association between recent vaccination and ITP in dogs. ANIMALS:
Forty-eight client-owned dogs with presumptive idiopathic ITP and 96 age-matched, client-owned dogs with non-immune-mediated disease. METHODS:
Retrospective, case-control study. Dogs were identified through the Veterinary Medical Database (VMDB) and Hospital Information System at Purdue University. RESULTS:
The median age at presentation for dogs with ITP was 7 years (range: 2-15 years). The majority of the ITP group was comprised of mixed breed dogs (38%); no pure breed was represented by more than 3 cases. The number of dogs that were vaccinated within 42 days of diagnosis of ITP did not differ significantly (P = .361) between cases of presumptive ITP (4/48, 8%) and the control group (13/96, 14%). CONCLUSIONS AND CLINICAL IMPORTANCE:
This study failed to confirm the presence of an association between presumptive idiopathic ITP in dogs and recent vaccination; however, the possibility of an association cannot be completely ruled out based on the small sample populations and requires further investigation."
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